Cancer Targeted Technology Commences Phase I Clinical Trial in Prostate Cancer Patients with an Innovative Radiotherapy, CTT1403, and Receives a $3.2M NIH Grant to Fund the Trial

Published: Jul 16, 2019 13:30 UTC

Cancer Targeted Technology (CTT), a privately-held Seattle-based biotechnology company, announced today that it has started treating patients with advanced stage prostate cancer with its radiotherapeutic drug, CTT1403, in a Phase I clinical trial. The clinical trial is being conducted at University of California, San Francisco in collaboration with Dr. Rahul Aggarwal as Principal Investigator.

CTT1403 targets Prostate Specific Membrane Antigen (PSMA). PSMA is overexpressed on greater than 90% of all prostate cancer and the amount of expression increases as the cancer spreads. Two features make CTT1403 unique and unlike other PSMA-targeted drugs currently in development: 1. CTT’s molecules bind irreversibly to PSMA and this distinctive mode of binding enhances rapid uptake of the drug within the tumor; and 2. CTT1403 contains an albumin binding component that increases circulation of the drug in the body and further increases the dose of drug that accumulates at the tumor sites. CTT1403 is labeled with the radionuclide Lutetium-177 and once delivered to the tumor, the radionuclide leads to tumor cell destruction.

On July 5th, 2019, the NIH announced that it was awarding CTT a competitive Small Business Innovation Research (SBIR) Phase IIB grant for ~$3.2M (over 3 years) to help fund the clinical trial and further the development of CTT1403. “We are very excited to receive this grant as it makes possible the Phase I clinical trial with CTT1403 in men suffering from advanced prostate cancer. Targeting the PSMA biomarker is revolutionizing how we think of both diagnosing and treating prostate cancer and CTT1403, with its well-designed and specific mode of binding, has the potential to be both safe and more efficacious against prostate cancer than current therapies,” stated Dr. Beatrice Langton-Webster, CTT’s CEO and Principal Investigator on the grant. The unique chemical structure for CTT1403 was conceived of by Dr. Cliff Berkman, Professor of Chemistry at Washington State University (WSU), who commented, “We are grateful for the commitment and dedication of our team to help advance this unique drug from bench-to-bedside so quickly.” The preclinical work on CTT1403 was conducted by Dr. Carolyn Anderson, Professor of Radiology, and colleagues at the University of Pittsburgh.

CTT recently completed clinical trials at UCSF with CTT1057, the companion PET diagnostic to CTT1403, with excellent safety and imaging results. CTT1057 is undergoing further development and commercialization by CTT’s licensing partner AAA/Novartis. CTT1057 and CTT1403 are intended to act as a theranostic pair to both diagnose and treat prostate cancer and are being used together in the current Phase I clinical trial. More information on the trial can be found at (NCT03822871).

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Cancer Targeted Technology
Dr. Beatrice Langton-Webster